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Research in Child and Adolescence Psychopathology

Empirical research: answering questions with confidence

Observational Research

  • Descriptive Research (observational research)
  • Exploratory studies
  • Case studies
    • illustrate, facilitate recall, entertain
    • but can any conclusions be generalized to other cases?
      • are the reported results accurate?
        • Do aggressive children grow up to be aggressive adults?
          • How do we identify aggression?
          • Does aggression in a child look like aggression in an adult?
        • form (topology) vs. function
          • B.F. Skinner and behavior
            • lever pressing in a rat: a functional definition of behavior
          • but in real life function can be difficult to assess
            • Lovaas’ video and “aggression” among some teenage boys
        • reliability of observational data
        • reliability of observational data
      • are the results representative?
        • sampling
          • population studies vs. clinic studies
          • Do we know what the relevant variables are ? (age, gender, intelligence, hair color [subject state variables]; hunger, degree of arousal, fatigue, color of shirt [subject state variables]; SES of family, urban/rural, nationality [environment trait-like variables]; parent presence, substitute teacher, winter, full moon [environmental state-like variables])
          • How often do we observe, where, how?
        • How situationally specific is the behavior we are interest in?

Epidemiological studies

San Diego Cohort, 1981 (Kraus et al., 1990)

  • Dead at scene/DOA 5%
  • Severe brain injury 6%
  • Moderate brain injury 8%
  • Mild brain injury 82%
  • <1 year of age 4%
  • 1-4 year of age 15%
  • 5-9 year of age 19%
  • 10-14 year of age 20%
  • 15-19 year of age 43%
  • male: 293.0 per 100,000
  • female 137.9 per 100,000
  • incidence of brain injury 2.1 times higher for males
  • External causes of brain injuries:
    • Motor vehicle 37%
    • Falls 24%
    • Assault 10%
    • Sports/recreation 21%
    • other 8%
  • Estimate of national disabilities:
    • assumptions:
      • 1. overall incidence rate of hospitalized brain injured person in U.S. of 210 per 100,000 persons aged 0 to 19 years
      • 2. U.S. population of 74,255,000 persons aged 0 to 19 years in 1986
      • 3. severity proportions of 86% mild, 8% moderate, and 6% severe
      • 4. in-hospital case-fatality rates of 0%, 2%, and 42% per 100 patients, respectively, by severity
      • 5. disability rates (any neurologic limitation or disability on hospital discharge) of 10%, 90%, and 100% for mild, moderate, and severe brain injury
    • Then:
      • About 29,000 persons aged 0 to 19 years have a resultant disability each year from brain injury.

Correlational Research

  • identifying patterns and relationships
  • Are variables associated?
    • correlation coefficients
    • measuring the strength of an association
      correlations, negative and positive
      -1     -.5    0      +.5   +1
  • “Third body problems” and the search for causes
  • William C. McGrew (1972) An Ecological Study of Children’s Behavior
    • studied “agonistic behavior” in preschool children in England
    • very “molecular” elements of behavior
      • threat, verbal: “I’m gonna hit you”
      • threat, physical: dominant arm raised
        • wrist cock
        • hit
    • conditional probabilities
      • neither verbal threats nor physical threats strongly predicted actual blows; however, if the wrist rotated (“wrist cock”), there was a high probability of a strike

9-12-13

Experimental Research (casual explanations, cause and effect)

  • Experimental research attempts to create conditions in which we can conclude that one variable causes another.
    • What do we mean when we say one thing “causes” another?
  • Variables: What are we interested in?
    • Dependent variable: the qualities we are interested in understanding (effect)
    • Independent variable: the qualities we manipulate to see what effect occurs with the dependent variable (cause)
  • How can we know if the Independent Variable affects the Dependent Variable?
    • Creating conditions in which no other explanation seems viable: No other explanation makes any sense.
    • Are our results reliable?
      • Reliability is always about consistency: if we look again, do we find the same thing?
    • Are our results valid?
      • Validity is about what this means (some would say “truth”): do these results mean what we think they mean?
  • Threats to validity:
    • Internal validity: do our results demonstrate what we believe (wish) these results to demonstrate?
    • External validity (generalizability): do our results apply to anyone beyond the group we worked with?
  • Issues in internal validity:
    • alternative explanations for our results
      • some problems of children tend to remit of time: “spontaneous recovery”
      • within a group of children with a problem, some wil get better
    • Control Groups
      • placebo effects and psychotherapy/drug research
        • classical medication study:
          • patients with a problem
          • are randomly assigned to one of two groups:
            • Group A (medication)
            • Group B (placebo)
          • treatment prceeds until a comparison is made: Does Group A do better than Group B? [We actually expect that both groups will improve somewhat and both groups will have some undesired “side effects”]
          • for “medication” you can substitute any “active treatment” versus “control”[comparison group]
            • Group A [new medication]
            • Group B [currently accepted medication]
              • or
            • Group A (new psychological treatment)
            • Group B (UCT: “usual and customary treatment” or “usual and customary care)
              • or
            • Group A (new psychological treatment)
            • Group B (UCT)
            • Group C (waiting list control group)
        • random assignment (why selection studies are not experimental)
    • detection of differences
      • real differences might be small (and likely to be missed)
      • real differences (valid) may also be trivial (relatively unimportant in the real world)
      • significance testing
    • measurement error
      • quality of our measure
      • sample size
      • significance testing

Issues in external validity

  • sampling: Is the group we studied representative of the population we wish to draw conclusions about?
  • How are populations described?
    • Do we know what the important variables are?
    • Lovaas’ autism treatment research
      • groups randomly assigned and then observed to be similar on:
        • symptoms of autism
        • diagnosis of “autism” by independent psychologist or psychiatrist
        • age of set [prognostic variable in literature]
        • tested intelligence [prognostic variable in literature]
        • porportion of males/females [sex difference in prevalence widely reported in literature; possible differential prognosis of males vs. females]
        • functional language [prognostic variable in literature]
      • the outcome saw clear superiority of positive changes in more of the “intensive treatment” than “usual and customary treatment” groups
      • Lovaas attributed this to the new treatment program
      • some critics questioned whether the children had “really been autistic”: that is, they did not question the good outcome but rather these results had implications for treating children who were “really autistic”

Ethics in research on child psychopathology

  • sources of ethical guidance in research
    • laws
    • government regulations governing grant funding
    • ethical standards of professional associations
    • institutional policies
    • conscience and personal morality
  • What makes research ethical?
    • Informed consent of participants
      • voluntary
        • freedom from coercion
          • negative coercion (threat, bullying, intimidation)
          • positive coercion (excessive positive rewards)
        • freedom to withdraw
    • informed
      • risk
        • clear communication of risks
        • procedures for identifying and dealing with untoward consequences
      • purpose
      • freedom to withdraw and consequences
    • Who can give consent?
      • competence (often assumed due to status)
      • status (adult)
      • vulnerable populations (e.g., children, prisoners, pregnant women)
      • From children we may seek “assent” [they agree to participate–this has no legal standing], from parents/guardians we must seek “consent”
    • Quality of research
      • unbiased, objective, clearly conceptualized
        • makes a contribution to our shared knowledge and understanding
        • potential benefits outweigh potential risks
      • results communicated accurately and responsibly
        • honesty in reporting results
        • data/methods made available to others for replication
    • Integrity of researcher
      • public acknowledgement of potential conflicts of interest
        • disclosure of financial entanglements
        • source of funding
      • accurate acknowledgment of contributions of others
        • credit for contributions to the research: authorship
        • credit for contributions to conceptualization: references
          • plagiarism
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