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Andrew  Mitchell
Andrew  Mitchell
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Principal Investigator​


Andy Mitchell obtained a B.S. in Chemistry at Grove City College (PA) in 2001. He joined the research group of Prof. Daniel Romo at Texas A&M University and completed his Ph.D. in 2008. After a postodoctoral appointment with Prof. Jeffrey W. Bode (now at ETH-LOC in Zurich, Switzerland) at the University of Pennsylvania, he joined the Department of Chemistry at Illinois State University as an Assistant Professor in 2010. He was promoted to Associate Professor with tenure in 2016.





Illinois State University
Department of Chemistry
Campus Box 4160
Normal, IL 61790-4160

Office: SLB Room 311
Office Phone: (309) 438–2697
Fax: (309) 438-5538 (dept)



Illinois State University, Normal, IL (2016-present)

Associate Professor, Department of Chemistry

Illinois State University, Normal, IL (2010-2016)
Assistant Professor, Department of Chemistry

University of Pennsylvania, Philadelphia, PA (2008-2010)
Postdoctoral Advisor: Professor Jeffrey W. Bode

Texas A&M University, College Station, TX (Ph.D. Chemistry, 2008)
Doctoral Advisor: Professor Daniel Romo

Grove City College, Grove City, PA (B.S. Chemistry, 2001)
Undergraduate Advisor: Professor Harold L. Conder



Kaufman, R. H; Law, C. M.; Simanis, J. A.; Woodall, E. L.; Zwick, C. R.; Wedler, H. B.; Wendleboe, P.; Hamaker, C. H.; Goodell, J. R.; Tantillo, D. J.; Mitchell, T. A. Oxidopyrylium-Alkene  [5 + 2] Cycloaddition Conjugate Addition Cascade (C3) Sequences: Scope, Limitation, and Computational Investigations. J. Org. Chem. 2018Just Accepted. ​Link​

Olson, C. A.; Shaner, C. E.; Roche, S. C.; Ferrence, G. M.; Mitchell, T. A. "Hexahydro-1H-Isoindolinone-Like Scaffolds from Electronically Deactivated and Sterically Hindered Dienes;Synthesis in the Context of Muironolide A." Synthesis 2015, 47, 2756-2766. Link​

Simanis, J. A.; Zwick, C. R.; Woodall, E. L.; Goodell, J. R.; Mitchell, T. A. “Further Investigation of Pyranone Activation.” Heterocycles 2015, 91, 149-156. Link 

Simanis, J. A.; Law, C. M.; Woodall, E. L.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. “Investigation of Oxidopyrylium-Alkene [5+2] Cycloaddition Conjugate Addition Cascade (C3) Sequences.” Chem. Commun. 2014, 50, 9130-9133.Link

Shaner, C. E.; Ferrence, G. M.; Mitchell, T. A. “Synthetic Efforts toward the Isoindolinone Core of Muironolide A.” Synlett 2013, 24, 1861-1864. Link

Woodall, E. L; Simanis, J. A.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. “Unique Reactivity of anti– and syn-Acetoxypyranones en Route to Oxidopyrylium Intermediates Leading to a Cascade Process.” Org. Lett. 2013, 15, 3270-3273. Link

Zhao, C.; Mitchell, T. A.; Vallakati, R.; Pérez, L. M.; Romo, D. “Mechanistic Investigations of the ZnCl2-Mediated Tandem Mukaiyama Aldol-Lactonization (TMAL): Evidence for Asynchronous Concerted Transition States and Discovery of 2-Oxopyridyl Ketene Acetal Variants,” J. Am. Chem. Soc. 2012, 134, 3084-3094. Link

Vo, C.-V. T.; Mitchell, T. A.; Bode, J. W. “Expanded Substrate Scope and Improved Reactivity of Ether-Forming Cross-Coupling Reactions of Organotrifluoroborates and Acetals,” J. Am. Chem. Soc. 2011, 133, 14082-14089. Link

Mitchell, T. A.; Bode, J. W. “Synthesis of Dialkyl Ethers from Organotrifluoroborates and Acetals,” J. Am. Chem. Soc. 2009, 131, 18057–18059.  Link     

Mitchell, T. A.; Zhao, C.; Romo, D. “Diastereoselective, Three-Component Cascade Synthesis of Tetrahydrofurans and Tetrahydropyrans Employing the Tandem Mukaiyama Aldol-Lactonization Process,” J. Org. Chem. 2008, 73, 9544–9551. Link

Mitchell, T.A.; Zhao, C.; Romo, D. “Highly Diastereoselective, Tandem, Three-Component Synthesis of Tetrahydrofurans from Ketoaldehydes via Silylated β-Lactone Intermediates,” Angew. Chem. Int. Ed. 2008, 47, 5026–5029.  Link 

Mitchell, T. A.; Romo, D. “Diastereoselective Synthesis of Tetrahydrofurans via Mead Reductive Cyclization of Keto-β-Lactones Derived from the Tandem Mukaiyama Aldol-Lactonization (TMAL) Process,” J. Org. Chem. 2007, 72, 9053–9059.  Link 

Mitchell, T. A.; Romo, D. “Radical Reactions and α-Silylations of Optically Active 4-Trichloromethyl-β-Lactone,” Heterocycles, 2005, 66, 627–637.  Link