Dr. John Goodell
Dr. Goodell received his B.S. in Chemistry from the University of Wisconsin-River Falls in 2000. He joined the research group of Prof. David Ferguson at University of Minnesota and completed his Ph.D. in Medicinal Chemistry in 2006 with a focus on the synthesis and evaluation of heterocyclic anti-viral agents. He then spend 4 years as a postdoctoral associate at the Center for Chemical Methodology and Library at Boston University (CMLD-BU) under the supervision of Prof. John Porco. His projects included the development of an automated microfluidics reactor platform in collaboration with MIT and Pfizer, Inc. and the discovery of novel chemotypes using multidimensional reaction screening in collaboration with Merck, Inc. and Jeffrey Aubé at University of Kansas. Dr. Goodell left the CMLD-BU in late 2010 to work with Prof. Peter Wipf at the University of Pittsburgh Center for Chemical Methodologies & Library Development (UP-CMLD) where he worked on the development and synthesis of medium sized libraries.
EDUCATION
Illinois State University, Normal, IL (2011-present)
Research Associate (Civil Service), Chemistry Department
University of Pittsburgh, Pittsburgh, PA (2010-2011)
Postdoctoral Advisor: Professor Peter Wipf
Boston University, Boston, MA (2006-2010)
Postdoctoral Advisor: Professor John Porco
University of Minnesota, Minneapolis, MN (Ph.D. Medicinal Chemistry, 2006)
Doctoral Advisor: Professor David Ferguson
University of Wisconsin, River Falls, WI (B.S. Chemistry, 2000)
PUBLICATIONS
Compton, D. L.; Goodell, J. R.; Berhow, M. A.; Kenar, J. A.; Cermak, S. C.; Evans, K. O. Feruloylated Products from Cocunut Oil and Shea Butter. Journal fo the American Oil Chemists’ Society, 2017, pp. 1-15.
Compton, D. L.; Goodell, J. R.; Grall, S.; Evans, K. O.; Cermak, S. C. Continuous, packed-bed, enzymatic bioreactor production and stability of feruloyl soy glycerides. Industrial Crops and Products, 2015, 77, 787-794.
Simanis, J. A.; Zwick, C. R.; Woodall, E. L.; Goodell, J. R.; Mitchell, T. A. Further Investigation fo Pyranone Activation. Heterocycles, 2015, 91, 149-156.
Benoit, A. R.; Schiaffo, C.; Salomon, C. E.; Goodell, J. R.; Hiasa, H.; Ferguson, D. Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3014–3017
Simanis, J. A.; Law, C. M.; Woodall, E. L.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. Investigation of Oxidopyrylium-Alkene [5+2] Cycloaddition Conjugate Addition Cascade (C3) Sequences. Chem. Commun. 2014, 50, 9130-9133.
Martin, V. I.; Goodell, J. R.; Ingham, O. J.; Porco, J. A.; Beeler, A. B. Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes. J. Org. Chem. 2014, 79, 3838-3846.
LaPorte, M. G.; Goodell, J. R.; Tsegay, S.; Wipf, P. (2013) Chapter 5: Domino Reactions in Library Synthesis. In. A. Trabocchi (Ed.) Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology (pp. 135-176). John Wiley & Sons, Inc.
Woodall, E. L; Simanis, J. A.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. Unique Reactivity of anti– and syn-Acetoxypyranones en Route to Oxidopyrylium Intermediates Leading to a Cascade Process. Org. Lett. 2013, 15, 3270-3273.
Brummond, K. M.; Goodell, J. R.; LaPorte, M. G.; Wang, L.; Xie, X.-Q. Synthesis and In Silico Screening of a β-Carboline-Containing Compounds. Beilstein J. Org. Chem.2012, 8, 1048.
Pimparkar, Ketan; Yen, Bernard; Goodell, John R.; Martin, Veronique I.; Lee, Wen-Hsuan; Porco, John A., Jr.; Beeler, Aaron B.; Jensen, Klavs F. Development of a Photochemical Microfluidics Platform. J. Flow Chem., 2011, 2, 53.
Goodell, John R.; Poole, Jennifer L.; Aubé, Jeffery; Beeler, Aaron B.; Porco, John A., Jr Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes. J.Org. Chem., 2011,76, 9792.
Goodell, John R.; Beeler, Aaron B.; Porco, John A., Jr. Multidimensional Screening of Condensation Reactions: Application to Asymmetric 1,2-Diketones and a-Hydroxyketones. Synthesis, 2010, 13, 2254.
Treece, Jennifer L.; Goodell, John R.; Velder, David V.; Porco, John A., Jr.; Aubé, Jeffery. Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Bicyclic Iminium Ethers. J. Org. Chem. 2010, 75, 2028.
Giri, Rajan, Goodell, John R.; Xing, Chenguo; Benoit,Adam; Hiasa, Hiroshi; Ferguson, David M. Synthesis and Cancer Cell Cytotoxicity of Substituted Xanthenes. Bioorg. Med. Chem. 2010 18, 1456.
Goodell, John R.; McMullen, Jonathan P.; Zaborenko, Nikolay; Maloney, Jason R.; Ho, Chuan-Xing; Jensen, Klavs F.; Porco, John A. Jr.; Beeler, Aaron B. Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds. J. Org. Chem.2009, 74, 6169-6180.
Oppegard, Lisa M.; Ougolkov, Andrei V.; Luchini, Doris N.; Schoon, Renee A.; Goodell, John R.; Kaur, Harneet; Billadeau, Daniel D.; Ferguson, David M.; Hiasa, Hiroshi. Novel Acridine-Based Compounds that Exhibit an Anti-Pancreatic Cancer Activity are Catalytic Inhibitors of Human Topoisomerase II. Eur. J. Pharm. 2009, 602(2-3), 223-229.
Goodell, John R.; Ougolkov, Andrei V.; Hiasa, Hiroshi; Kaur, Harneet; Remmel, Rory; Billadeau, Daniel D.; Ferguson, David M. Acridine-Based Agents with Topoisomerase II Activity Inhibit Pancreatic Cancer Cell Proliferation and Induce Apoptosis. J. Med. Chem. 2008, 51(2), 179-182.
Goodell, John; Madhok, Avni; Hiasa, Hiroshi; Ferguson, David. Synthesis and Evaluation of Acridine- and Acridone-Based Anti-Herpes Agents with Topoisomerase Activity. Bioorg. Med. Chem. 2006, 14(16), 5467-5480.
Goodell, John; Svensson, Bengt; Ferguson, David. Spectrophotometric Determination and Computational Evaluation of the Rates of Hydrolysis of 9-Amino-Substituted Acridines. J. Chem. Inf. Model.2006, 46(2), 876-883.
Goodell, John; Puig-Basagoiti, Francesc; Forshey, Brett; Shi, Pei-Yong; Ferguson, David. Identification of Compounds with Anti-West Nile Virus Activity. J. Med. Chem.2006, 49(6), 2127-2137.
Wang, Xiaodong; Hart, Scott; Xu, Bailing; Mason, Matthew; Goodell, John; Etzkorn, Felicia. Serine-cis-proline and Serine-trans-proline Isosteres: Stereoselective Synthesis of (Z)- and (E)-Alkene Mimics by Still-Wittig and Ireland-Claisen Rearrangements. J. Org. Chem. 2003, 68, 2343-2349.
Patents
Ferguson, David M.; Goodell, John R.; Hiasa, Hiroshi; Slaton, Joel W.; Billadeau, Daniel D. Antitumor Catalytic Topoisomerase II Inhibitors. PCT Int. Appl. (2009), 58pp. CODEN: PIXXD2 WO 2009076212 A1 20090618 CAN 151:70263 AN 2009:737713
Ferguson, David M.; Goodell, John R. Pyrazoline Derivatives for Treatment of Viral Infections. PCT Int. Appl. (2007), 78pp. CODEN: PIXXD2 WO 2007038425 A2 20070405 CAN 146:395241 AN 2007:384400
Professional Presentations
Oral Presentations
“Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones” ACS National Meeting,Boston, August 22, 2010.
“Developing Technologies for Reaction Discovery” Cambridge Healthtech Institute: High-Throughput Organic Synthesis & Purification Conference,La Jolla,California, May 15, 2007.
“Discovery and Development of Compounds with Anti-West Nile Virus Activity,” American Chemical Society: the 37th Great Lakes Regional Meeting, Milwaukee, Wisconsin, June 2, 2006.