Publications – Dr. Kyle A. Floyd

2024

Potapova A, Garvey W, Dahl P, Guo S, Chang Y, Schwechheimer C, Trebino MA, Floyd KA, Phinney BS, Liu J, Malvankar NS, Yildiz FH. Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly. mBio. 2024 Feb 14;15(2):e0330423. doi: 10.1128/mbio.03304-23. Epub 2024 Jan 11. PubMed PMID: 38206049; PubMed Central PMCID: PMC10865864.

Hughes HQ, Floyd KA, Hossain S, Anantharaman S, Kysela DT, Zöldi M, Barna L, Yu Y, Kappler MP, Dalia TN, Podicheti RC, Rusch DB, Zhuang M, Fraser CL, Brun YV, Jacobson SC, McKinlay JB, Yildiz FH, Boon EM, Dalia AB. Nitric oxide stimulates type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7). doi: 10.1073/pnas.2108349119. PubMed PMID: 35135874; PubMed Central PMCID: PMC8851539.

Wong GCL, Antani JD, Lele PP, Chen J, Nan B, Kühn MJ, Persat A, Bru JL, Høyland-Kroghsbo NM, Siryaporn A, Conrad JC, Carrara F, Yawata Y, Stocker R, V Brun Y, Whitfield GB, Lee CK, de Anda J, Schmidt WC, Golestanian R, O’Toole GA, Floyd KA, Yildiz FH, Yang S, Jin F, Toyofuku M, Eberl L, Nomura N, Zacharoff LA, El-Naggar MY, Yalcin SE, Malvankar NS, Rojas-Andrade MD, Hochbaum AI, Yan J, Stone HA, Wingreen NS, Bassler BL, Wu Y, Xu H, Drescher K, Dunkel J. Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Phys Biol. 2021 Jun 23;18(5). doi: 10.1088/1478-3975/abdc0e. Review. PubMed PMID: 33462162; PubMed Central PMCID: PMC8506656.

Schwechheimer C, Hebert K, Tripathi S, Singh PK, Floyd KA, Brown ER, Porcella ME, Osorio J, Kiblen JTM, Pagliai FA, Drescher K, Rubin SM, Yildiz FH. A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. PLoS Pathog. 2020 Aug;16(8):e1008745. doi: 10.1371/journal.ppat.1008745. eCollection 2020 Aug. PubMed PMID: 32841296; PubMed Central PMCID: PMC7485978.
Floyd KA, Lee CK, Xian W, Nametalla M, Valentine A, Crair B, Zhu S, Hughes HQ, Chlebek JL, Wu DC, Hwan Park J, Farhat AM, Lomba CJ, Ellison CK, Brun YV, Campos-Gomez J, Dalia AB, Liu J, Biais N, Wong GCL, Yildiz FH. c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae. Nat Commun. 2020 Mar 25;11(1):1549. doi: 10.1038/s41467-020-15331-8. PubMed PMID: 32214098; PubMed Central PMCID: PMC7096442.
Wu DC, Zamorano-Sánchez D, Pagliai FA, Park JH, Floyd KA, Lee CK, Kitts G, Rose CB, Bilotta EM, Wong GCL, Yildiz FH. Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation. PLoS Genet. 2020 Mar;16(3):e1008703. doi: 10.1371/journal.pgen.1008703. eCollection 2020 Mar. PubMed PMID: 32176702; PubMed Central PMCID: PMC7098655.

Eberly AR, Floyd KA, Beebout CJ, Colling SJ, Fitzgerald MJ, Stratton CW, Schmitz JE, Hadjifrangiskou M. Biofilm Formation by Uropathogenic Escherichia coli Is Favored under Oxygen Conditions That Mimic the Bladder Environment. Int J Mol Sci. 2017 Sep 30;18(10). doi: 10.3390/ijms18102077. PubMed PMID: 28973965; PubMed Central PMCID: PMC5666759.
Shaffer CL, Zhang EW, Dudley AG, Dixon BREA, Guckes KR, Breland EJ, Floyd KA, Casella DP, Algood HMS, Clayton DB, Hadjifrangiskou M. Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli. Infect Immun. 2017 Jan;85(1). doi: 10.1128/IAI.00471-16. Print 2017 Jan. PubMed PMID: 27795353; PubMed Central PMCID: PMC5203662.
Floyd KA, Eberly A, Hadjifrangiskou M. Adhesion of bacteria to surfaces and biofilm formation on medical devices. In: Biofilms and Implantable Medical Devices [Internet] Elsevier; 2017. 47-95p. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780081003824000034.

Floyd KA, Mitchell CA, Eberly AR, Colling SJ, Zhang EW, DePas W, Chapman MR, Conover M, Rogers BR, Hultgren SJ, Hadjifrangiskou M. The UbiI (VisC) Aerobic Ubiquinone Synthase Is Required for Expression of Type 1 Pili, Biofilm Formation, and Pathogenesis in Uropathogenic Escherichia coli. J Bacteriol. 2016 Oct 1;198(19):2662-72. doi: 10.1128/JB.00030-16. Print 2016 Oct 1. PubMed PMID: 27161114; PubMed Central PMCID: PMC5019064.

Floyd KA, Meyer A, Nelson G, Hadjifrangiskou M. The yin-yang driving urinary tract infection and how proteomics can enhance research, diagnostics, and treatment. PROTEOMICS – Clinical Applications. 2015 September; 9(11-12):990-1002. doi: 10.1002/prca.201500018.
Floyd KA, Meyer AE, Nelson G, Hadjifrangiskou M. The yin-yang driving urinary tract infection and how proteomics can enhance research, diagnostics, and treatment. Proteomics Clin Appl. 2015 Dec;9(11-12):990-1002. doi: 10.1002/prca.201500018. Epub 2015 Sep 13. Review. PubMed PMID: 26255866.
Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M. Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili. PLoS Pathog. 2015 Mar;11(3):e1004697. doi: 10.1371/journal.ppat.1004697. eCollection 2015 Mar. PubMed PMID: 25738819; PubMed Central PMCID: PMC4349694.